What is SFN

What is Small Fiber Neuropathy?

Small Fiber Neuropathy (also known as Small Fiber Sensory Neuropathy, Small Fiber Peripheral Neuropathy, or C Fiber Neuropathy) is a disorder in which only the small sensory cutaneous nerves are affected. The majority of patients experience sensory disturbances that start in the feet and progress upwards.  Patients with small fiber neuropathy exhibit a reduction in the epidermal nerve fiber density (ENFD) or small fiber structural abnormalities associated with the neuropathy.

The most Common Symptoms include

  • pain
  • burning
  • numbness
  • pins and needles
  • tingling
  • restless leg syndrome
  • autonomic dysfunction
  • electric shock
  • Difficulty with temperature perception


SFN can quite often be idiopathic in origination.  However, there are several contributing factors that often attribute to the disease state.

  • Diabetes
  • HIV
  • Drug use
  • Alcoholism
  • Vasculitis
  • Genetic Disorders
  • Amyloidosis
  • Lyme Disease
  • Trauma